When two or more medicines are taken at the same time, the effects of one of the medicines can be altered by the other. This is known as a drug-drug interaction. Some antifungal medicines can interact with other medicines.


Tell your GP or pharmacist what other medicines you are taking, including over-the-counter medicines, so they can decide whether an antifungal medicine is safe for you to take.


Medicines that antifungal medicines may interact with include:


  • benzodiazepines – a group of medicines used to help sleep and reduce anxiety

  • ciclosporin – a medicine that suppresses the immune system (the body’s natural defence against illness and infection)

  • cimetidine – a medicine used to treat indigestion

  • hydrochlorothiazide – a medicine used to treat high blood pressure (hypertension)

  • oestrogens – hormones found in some contraceptives

  • phenytoin – a medicine used to treat epilepsy

  • progestogens – hormones found in some contraceptives

  • rifampicin – an antibiotic used to treat bacterial infections, such as tuberculosis

  • tacrolimus – a medicine that suppresses the immune system

  • theophylline – a medicine used to treat asthma

  • tricyclic antidepressants – medicines used to treat depression

  • zidovudine – a medicine used to treat HIV and AIDS


Interactions with other medicines