Multiple Myeloma: Is Your Bone Wellness is at Risk?

Multiple myeloma is a major health concern, as it affects the plasma cells in your body. These are the white blood cells that make antibodies, but when the cancer gets involved, abnormal plasma cells accumulate in your bones and bone marrow. This can have a damaging impact on your wellbeing, since the bone marrow is your body’s source of blood cells, so multiple myeloma interferes with the production of blood cells, and can lead to the development of bone lesions.

 

The problem with this type of cancer is that different varieties affect your wellness in different ways, and so some types are more recognisable than others. Indolent myeloma, for example, has no discernable symptoms. As it only develops slowly and does not cause bone tumours, the only things that may be seen are small increases in M plasma cells and M protein, which is an abnormal type of antibody found in myeloma patients. Solitary plasmocytoma, on the other hand, does involve a tumour which is usually found in one of your bones. This kind of multiple myeloma tends to respond well to treatment, but your doctor will have to monitor it closely.

 

As it stands, wellness experts are unsure as to what exactly causes multiple myeloma, but they do know that it begins with one abnormal plasma cell. When this cell multiplies in your bone marrow, it does so far more times than it should and – instead of multiplying and dying out like non-cancerous cells – it keeps dividing indefinitely. As a result, your body can become overwhelmed and start impairing the production of your healthy cells.

 

There aren’t many clear risk factors for multiple myeloma, but there are a few to watch out for:

 

1. Being over the age of 50 (although you’ll likely be diagnosed in your early to mid 60s)

2. Being male

3. Being of African origin

4. Being overweight or obese

5. Exposure to radiation

6. Having a job in the petroleum industry

7. Having a history of monoclonal gammopathy of undetermined significance (MGUS). At least 1% of people with MGUS will also develop multiple myeloma every year.

Categories: abnormal plasma, blood cells, bone, Bone Cancer, Bone Marrow, cells, multiple, multiple myeloma, myeloma, plasma cells

Gene Responsible for Ageing is also Linked to Blood Cancer

A recent study has established a link between the gene which is responsible for ageing and a higher risk of blood cancer. The study provides a glimpse into the relationship between the genes and their effects on cancer risk, thus making it possible to develop better treatment options. Blood cancer, especially myeloma, is a condition that cannot be cured. So scientists are looking into the possibility of identifying the threat of blood cancer, so that preventive measures may be taken in time, by studying the genetic makeup of a high-risk patient.

What is Blood Cancer?

Blood cancer begins in the bone marrow where production of blood takes place. In most blood cancers, the normal development of the blood cell is interrupted by their abnormal and rapid growth. These abnormal cells do not let the blood perform its normal functions, such as preventing bleeding or fighting infections. Because of this, the body loses its resistance, thus leading to a weak immune system.

 

Myeloma, a common type of blood cancer, affects the plasma cells. These plasma cells are nothing but the white blood cells which are responsible for producing antibodies that fight diseases and infections in the body. Myeloma causes a weakened immune system that is susceptible to infections.

 

According to statistics, nearly 4,700 patients are affected by myeloma every year due to genetic mutations. 4 out of 10 patients live through the disease for more than 5 years whereas 3 in 10 die within a year.

 

 

 

New Findings

Scientists at The Institute of Cancer Research London found that the gene which is responsible for ageing has links with blood cancer development as well. Researchers concluded that the gene that is responsible for the internal clock of the cell is also 50% responsible for one of the most common types of blood cancer known as myeloma. However, researchers also suggested that it does not mean that the cancer is inevitable for those with this gene. This major study helps shed light on the genetic causes of blood cancer.

 

Scientists had previously identified 3 genetic variants responsible for myeloma. The new study identified some more, thus bringing the total to 7 genetic variants. The study not only helps to understand the genetic reasons of blood cancer, but will also help researchers develop appropriate treatments for the disease. Identifying the genetic makeup of blood cancer will also help physicians assess the risk and formulate treatment plans accordingly.

 

Cancer is nothing but the abnormal division of cells. To control this abnormal growth, our body has an innate system that keeps a check on cell division. But as human beings age, the body loses its ability to keep those checks up, thus making it more susceptible to developing cancer. Those with a specific genetic makeup may become more easy targets of cancer.

 

Myeloma is incurable and has devastating effects on the body; the new study helps identify people who are at high risk of inheriting myeloma, thus significantly reducing the chances of someone developing this cancer. However, researchers also warn that before undergoing genetic testing, patients should be given counseling so that they are able to able to cope with the results of the test.

The new study has truly been a breakthrough in the medical community because it gives a glimmer of hope in the treatment of myeloma which is otherwise incurable.

 

 

 

Author Bio:

Sameer Gupta is a medical writer who writes well-researched, in-depth cancer articles which provide relevant information to help patients combat the deadly disease.

Categories: ageing, Blood Cancer, body loses, cancer nbsp, gene, genetic makeup, high risk, nbsp myeloma, nbsp nbsp, plasma cells, study helps