Dear Pharmacist: Two of my relatives have pancreatic cancer, and I’m worried sick for myself. No symptoms yet, but is tcan share with them, or take myself? — D.T., Sacramento, Calif.
I’m sorry to hear about your relatives. Pancreatic cancer is on the rise, with certain medications and foods and beverages increasing its risk. I wrote a book on the topic to help people.
Squashing free radicals is helpful, as well as pancreatic enzymes. Anything that slows growth or spreading is important. Detoxifying the body (particularly lymph) is probably No. 1 on my list. As a natural-minded pharmacist, I love finding research about natural plant extracts that work like pharmaceuticals.
There’s a protein in your body called mTOR (mammalian target of rapamycin) that plays a vital role in how each cell thrives, divides, or dies. When this protein and associated metabolic pathway is turned on too high, it promotes cancer spreading.
If we interfere with the mTOR pathway, it helps stop the formation of new blood vessels which feed the tumor. These mTOR “inhibitors” help people with pancreatic cancer and possibly induce remission, at least for awhile. This was shown in February 2011, in the Journal of Clinical Oncology, entitled, “mTOR Inhibitor Treatment of Pancreatic Cancer in a Patient with PJS.” The scientists used a drug called everolimus (Afinitor). Other mTOR inhere anything I hibitors available today include Certican and Torisel.
There are natural compounds which are known to interfere with mTOR, but to a lesser extent compared to these cancer drugs. Resveratrol is one of them as reported in The Journal of Biological Chemistry (Nov. 19, 2010). The scientists knew going into the study that resveratrol was a powerful herbal with strong antioxidant, anti-inflammatory, and nerve-protecting effects on the body.
Guess what other herb reduces mTOR activity? Curcumin, one of the active compounds in turmeric spice, is popular in Indian cuisine. Many studies prove curcumin slows down the growth of different types of cancer. Curcumin may be helpful for pancreatitis because it reduces inflammation in the pancreas and reduces inflammatory pain-causing chemicals.
Saffron also is amazing. This gorgeous flower is available as a spice and in supplement form. Saffron supplements seem to help reduce chemotherapy-induced cell damage (damage to the DNA). Crocetin, a carotenoid derived from saffron, appears to compete with the drug gemcitabine which is one of the standard therapies for pancreatic cancer. Remarkably, both the herb and the chemo drug compete for the same receptor site, which is the doorway into your cell. Are they trying to do the same good thing in there?
The discussion of using resveratrol, curcumin or saffron is between you and your doctor. Even though these are natural herbs, with excellent safety profiles, I have no idea what’s right for you and your safety is my first concern. Ask a licensed practitioner about customizing your personal health regimen.
