Showing posts with label stem cells. Show all posts
Showing posts with label stem cells. Show all posts

It’s common knowledge that if there is one aspect of your life will inevitably and irrevocably change your body, it is ageing.  We are all aware of aged or ageing relatives and the way that they have been changed by their battles with time. We naturally think of older people being more vulnerable to illness and disease, as well as being generally more fragile than they were when they were young. And it may well even be true that we place too much of an emphasis on cliché when we think of the old.


 


For so many people the first image that pops into their head when they think of old people in the wrinkled, dour old man with politically incorrect views and an aversion to change. They’re bad with technology, slow on the uptake and completely unwilling to change. But of course this is just the sort of stereotype that pigeonholes our opinions. So what is the truth of the matter? Let’s have a look at some scientifically valid examples of the way ageing actually changes us.


 


With regards to the belief in the rather right-wing-leaning opinions of the old, it seems that this might actually be more bluster than reality. According to one survey of more than 46,000 Americans taken between 1972 and 2004, adults’ attitudes became more liberal regarding their thoughts on politics, economics, gender, religion and even race and sexuality issues as they got older. While the survey did not look at the patterns of individuals, so we can’t tell whether conservative people specifically became more liberal as they aged, it was clear from the analysis that as people aged they were more likely to have a more tolerant attitude.


 


It also seems that it’s not only what’s on the outside physically that changes within our bodies, it is also our cells. Specifically we know that stem cells age just in the same way that other cells do. Stem cells are often thought of as being able to combat ageing as they replenish old or damaged cells, but it seems that they also feel the effects of the wear and tear of ageing. Research published in 2007 argues that stem cells’ regenerative abilities declines as you get older.


 


Another study showed that as we age we seem to naturally need less sleep – or at least this is one way of looking at the analysis that was presented. A study looked at the sleeping patterns of more than 100 healthy adults and allowed them eight hours of being in bed. The oldest group, who were aged from 66 to 83 slept for around 20 minutes less than people in middle age, consisting of those who were 40 to 55. The middle agers, in turn, slept 23 minutes less than the youngest group who were aged 20 to 30.


 


Becoming distracted more easily also appears to be a problem for older adults than it is for their younger counterparts. It seems to be true that as we age we find it more difficult to tune out the things going on around us and focus on just one thing at a time.


 


But perhaps the most predictable and common sign of ageing is certainly backed up by medical knowledge. We know very well that looking at the skin can be a very quick and easy way to ascertain if someone is ageing. It seems that this is partially down to the outer layer of the skin – known as the epidermis – thinning as we get older. This combines with the fact that the skin becomes less supple as the years mount up.

Stem cells are being hailed for their use in multiple aspects of wellbeing, but now they may be able to improve your anti-ageing wellness. However, this discovery was a bit of an accident. Sydney cosmetic doctor and stem cell clinician Ralph Bright explains, ‘I’ll never forget the woman whose knee was injected with stem cells to repair it, and came back two months later saying her skin on her face was smoother and more elastic. We hadn’t touched her face.’


 


Now, stem cell derivatives are starting to be used in a new generation of face creams, but what makes them so effective? According to Sydney surgeon Bill Lyon, ‘many people believe stem cells are the holy grail in many aspects of medicine with excellent results. In animal experiments, stem cells have been shown to improve skin quality and integrity. They are thought to replenish the aged cells and tissues within the skin.’ This was the thought behind Luminesce, a range of creams and serums – created by US cosmetic company Jeunesse – which contain cytokines. These are the stem-cell derived messengers that communicate between stem cells within your body.


 


Brand spokesperson Vincent Giampapa, a New York plastic surgeon and anti-ageing doctor, comments, ‘Growth factors or cytokines are the cell’s language. In other words, the way thousands of cells communicate allowing them to do one vital function – repair and regenerate the tissue in the body. These cytokines are packed with vitamins and nutrients to nourish skin, and send signals to the body to slow down the signs of ageing . After extraction, the stem cells go through an extensive process to isolate the cytokines. These are in the creams. It is important to understand these stem cells and their receptors are extracted from the fat cells of grown adults. Human adult fat cells are packed with stem cells.’


 


Dr Bright notes, ‘You cannot keep stem cells active in a cream, so the use of cytokines, the cell’s messengers if you like is the closest we can get in a cream.’ However, Dr Lyon is sceptical. ‘Cosmeceuticals with stem cell extracts will work as well as any other product as long as the base ingredients are effective,’ he says. ‘The problem with any topically derived cream is getting the ingredients through the barrier [the skin] unchanged and still active. If this has been achieved they could be effective.’

When your wellness is affected by back pain, the underlying cause tends to be problems with your discs. These are the cushions between the bones of your spine, which work as shock absorbers. Unfortunately, there aren’t very many successful treatments, but in some cases there is one option; rejuvenating the disc with your own stem cells.


Dr. Andrew Cappucino has been helping develop a technique of removing your stem cells from the bone marrow and injecting them into damaged discs. In one treatment, he removes your bone marrow, separates the stem cells and then injects them into the discs. Although this isn’t the right course of treatment for everyone, it’s likely to become very popular if it produces the long-term results that Dr. Cappuccino expects.


One person who’s also hoping that Dr. Cappuccino’s expectations hold up is patient Johna Lindell. Even though Johna had disc problems for several years, her wellbeing was more severely affected after her daughter Abby was born. According to Johna, ‘That was very frustrating, because I wasn’t able to carry her. Even as an eight-pound infant, I wasn’t able to carry her for a long time in a carrier or anything like that.’ Luckily, Johna’s husband is Rian Lindell, a kicker for the Buffalo Bills, an American football team. Rian’s team mate, Kevin Everett, was treated for a spine injury by Dr. Cappuccino, and so Rian put his wife in touch with the doctor.


When your discs are normal, they look white on an MRO scan because they contain water. However, when Johna had just such a scan, Dr. Cappuccino noted a typical abnormality. He explained, ‘You can see that those three disks have turned black, dark. They’ve lost their water content, so they are losing their ability to be a shock absorber, and they’re beginning to bulge out into the spinal canal.’ After the procedure, ‘the needles were removed, band-aids were placed, she went to the recovery room, and an hour and 15 minutes later, she was on her way home,’ Dr. Cappuccino said.


Although it will take months for her to feel the full benefit, in the nine days since the treatment, Johna’s felt a daily improvement. She enthused, ‘I feel better every day when I get up out of bed and I notice that I’m happier, because I can get up and I can function and I can go in and get my daughter and I can get her ready and I’m not shuddering with pain.’ As Dr. Cappuccino said, ‘We see statistically significant decreases, almost back to the normal range, in patients that have had disabling pain for years,’ Johna added, ‘I’m happy to be part of something that I really think is going to be bigger in the future.’

Stem cells are biological cells that can transform into any type of cell in the body and have the ability to renew themselves through cell division. They can develop into multiple cell types, such as blood cells, cells of the heart, skin, bones, muscles, brain, or others. Due to federal funding now available for stem cell research, scientists can now study medical treatments for many diseases that cord tissue could alleviate or treat:


 


ALZHEIMER’S DISEASE


A progressive, deadly brain disorder that destroys nerve cells in the brain, Alzheimer’s causes memory loss, behavioral changes, and loss of thinking/language skills. Previously, research for this disease has been done on animals, and has been ineffective because there is no animal “equivalent” to Alzheimer’s. Researchers are creating cell models of this disease in the lab using cells directly from Alzheimer’s patients, and testing new drugs on the human cells.


 


SPINAL CORD INJURY


Spinal cord injuries, including paralysis, include about 250,000 people in the U.S. The first trial that used humans to test embryonic stem cells was targeted to create ways to implant cells that could transmit nerve signals to muscles, allowing volunteers to have feeling returned in their lower extremities.


 


PARKINSON’S DISEASE


Stiffness, tremors, movement and speech problems occur when nerve cells responsible for movement stop sending signals to dopamine neurons. There are drugs that can lessen Parkinson’s symptoms, but not cure. Stem cell researchers are developing new drugs by using cord tissue to reprogram human skin cells in the lab, and exposing them to new drugs to get a favorable response so they can test on humans.


 


HIV/AIDS


The Human Immunodeficiency Virus (HIV) infects the immune system, prevents the body from fighting disease, and can lead to AIDS, causing cancer, infections, and even death. Stem cells could replace the person’s blood-forming cells through bone marrow transplants that were resistant to HIV infections by boosting the immune system.


 


DIABETES


An autoimmune disorder, diabetes is a condition where the body’s immune system destroys its own pancreatic cells that make insulin. This prevents cells from using sugar for food, and as it backs up in the kidneys, causes damage to eyes, blood vessels, and kidneys. Transplanting the cells in the pancreas from donated organs has been an answer, but can be rejected. Researchers have created procedures to replace insulin producing cells with those developed from stem cells.

Studies have found that implants made from coral could help to renew knee joints in people suffering with osteo-arthritis. Helping to stimulate the growth of new tissue in the cartilage, through stem cells, this new medical technology could offer a great deal of hope for people who deal with this debilitating disease. The body’s own immature cells can develop into any type of tissue, including that in the joints. Those dealing with osteo-arthritis could be in luck, as this study offers promising results in the development of new treatments.


Researchers chose to use coral as its structure is closely linked to that of bones in the human body, which helps to provide the ideal scaffold for new blood vessels and cartilage to connect to. It’s thought that around eight million people in the UK have some variation of osteo-arthritis, which damages and destroys the cartilage – this is the body’s natural shock absorber which helps to reduce the impact from walking and running. Scientists worked with the coral segments by coating them in human growth factors, which encourage the development of new cells in the body.


Currently, there are no options with regards to medication for this condition, so people suffering with it are crippled with pain and swelling in the joints. Other risk factors, such as family history and weight impact the severity of the arthritis as well. Coral has been used in bone grafts for many years, as new cells need something to build from inside the body – coral works as a scaffold. This study offers hope for osteo-arthritis sufferers though, as researchers believe it could be used for cartilage replacements. Results from recent studies found that after six to twelve months, the stem cells had created a new layer of cartilage and the coral implant has dissolved.


 



Can Coral Help You to Treat Osteo-Arthritis?

freeze skinSitting in a deep-sea diving tank, combined with injections of your own stem cells, has emerged as a possible new treatment for type 2 diabetes, the most common form of the condition. This is according to a trial at Miami University, which found that patients were able to stop using insulin or metformin after a combination of bone-marrow stem cell injections in the pancreas, and five one-hour sessions of hyperbaric oxygen treatment.


According to the scientists, who published their work in the journal Cell Transplantation, the combination of stem cell therapy and hyperbaric oxygen treatment improves patients’ wellbeing, because the high levels of oxygen in the chamber boosts the activity of the stem cells. This helped the stem cells to repair the cells in the body that produce insulin, which thereby guards your wellness against the need for diabetes medications, such as insulin and metformin.


The new treatment is being investigated at a number of centres across the world. It involves extracting stem cells from the patient’s bone marrow under local anaesthetic and injecting them into the pancreas, after which the patient sits in a highly pressurised chamber, causing them to breathe in three times as much oxygen as they would normally. Hyperbaric oxygen treatment is currently used to help divers who have surfaced too quickly and have the ‘bends’ (where bubbles of nitrogen form in the blood).


For the Miami trial, 25 patients, who were taking either metformin, insulin or both, had five hour-long sessions of hyperbaric oxygen treatment before and after the injections, over the course of a week. The results were that four patients were able to stop using their insulin after the combined treatment, whilst another fifteen could gradually reduce their insulin over the following year. When it came to metformin, ten participants were also able to stopped or reduce their dose.


Dr Matthew Hobbs, Head of Research at Diabetes UK, commented on the use of stem cells in diabetes research: ‘Although any stem cell therapies for type 1 and type 2 diabetes are many years away from widespread clinical use, researchers agree that stem cells hold great potential to treat and perhaps even cure a range of different health conditions. Stem cell research is an exciting area of science that, in the long term, could help us bring about a future without diabetes.’



Need a New Diabetes Treatment? Try Deep-Sea Diving!

stem cellWhen you have a heart attack, injecting specialised cardiac stem cells into your heart can rebuild healthy tissue, and thus improve your wellbeing. However, though medical wellness experts already knew that stem cell therapy reduces scarring and regenerates healthy tissue, researchers have now demonstrated exactly how stem cells work to boost heart health.


The team at the Cedars-Sinai Heart Institute, whose 2012 clinical trial showed that stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack, now know that stem cells boost the production of your existing heart cells (cardiomyocytes) and spur the recruitment of existing stem cells that mature into heart cells. These findings are based on a laboratory animal study, which is published in EMBO Molecular Medicine online.


According to Eduardo Marbán, MD, PhD, director of the Heart Institute, the article’s senior author and inventor of the experimental stem cell procedures and technology tested in humans, ‘We’re finding that the effect of stem cell therapy is indirect. It stimulates proliferation of dormant surviving host heart tissue, and it attracts stem cells already in the heart. The resultant new heart muscle is functional and durable, but the transplanted stem cells themselves do not last long.’


The scientists found that your heart’s native stem cells are not responsible for the normal replenishment of lost heart cells, but they do play a role in rebuilding heart tissue after a heart attack, which is consistent with previous studies. Marbán’s team showed that dying heart cells are replaced by new ones through a gradual cycling process, which escalates in response to heart attack. This enables existing heart cells to aid the development of new ones – an effect which can be amplified through stem cell therapy.


Essentially, the injection of stem cells boosts your hearts usual means of cell replacement and injury response, by turning on the genes that bolster cell production from both existing heart cells and existing stem cells. The investigational therapy can also improve your heart’s structure and function. In the last few years, Marbán and his clinical and research teams have managed to use a heart attack patient’s own heart tissue to grow specialised stem cells that were injected back into the heart, as well as significantly reducing the size of heart attack-caused scars in patients who underwent the experimental stem cell procedure, compared to others who did not.


However, Marbán, the Mark S. Siegel Family Professor, allowed that though the preliminary results are positive, his team does not know precisely how the research treatment works. Yet, he said, ‘Understanding the cellular sources and mechanisms of heart regeneration is the first step toward refining our strategies to more effectively regenerate healthy tissue after heart attacks.’



How Do Stem Cells Work in Rebuilding Healthy Heart Tissue?

new studies heart healthNext year, Singapore is set to make progress in heart health research with the introduction of a new specialised cell bank. This facility will collect the stem cells of people with genetic cardiovascular diseases or those who are at higher risk of developing them, so that the scientists are able to study, and come up with patient-tailored treatments for, the diseases.


The bank will be located in the National Heart Centre Singapore’s new premises at Outram Park, which, when completed next year, will be the first in Asia. Those responsible for the development of the cell bank also hope that it may be used to test the cells of healthy people to predict the likelihood of future wellness problems, or to  heal diseased cells and use them for treatment.


According to Associate Professor Philip Wong, director of the centre’s research and development unit, skin samples collected from patients will be converted into induced pluripotent stem cells. These cells can develop into different types of cells, such as those of the bone, tissues and heart. In terms of assessing your risk of heart disease, a scientist can collect your skin sample, turn it into stem cells, grow those into heart cells and then look for genetic signs of the disease.


This type of procedure is far easier on your physical and financial wellbeing, as the investigator will be able to evaluate your risk of heart disease far more easily and inexpensively than it would be if he or she extracted the cells from your heart. According to Wong, ‘Even for children, for example, we can use this method as a “crystal ball” to check if they are likely to develop certain diseases.


In the July edition of the European Heart Journal, the scientists showed that their method can test early for signs of arrhythmogenic right ventricular cardiomyopathy – a rare inherited heart-muscle disease linked to sudden death among young men, and only usually detected at a late stage or after death. The team’s method could also be used to collected and repair your own diseased stem cells to then treat you with.


Wong explained, ‘If we find that the stem cell will grow into a diseased heart cell, we could find out how to repair it so it grows into a healthy heart cell. We could then implant the healthy engineered cells back in the patient’s body or use gene therapy to change the diseased cells in the body.’ He added that the method could prevent the children from developing the disease in the first place.



How is Singapore Set to Make Progress in Heart Research?