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Showing posts with label type. Show all posts
Showing posts with label type. Show all posts
Diabetes is a major health concern, with type 2 accounting for between 85 and 95% of all people with the disease. Type 2 diabetes, then, affects wellness in a big way, but a new pill looks set to change all that. The breakthrough treatment works to slash blood sugar levels and offers hope to the wellbeing millions of diabetes sufferers. And, if you’re thinking we’re talking about a “promising study” or “preliminary finding”, think again: the pill has now been launched in the UK.
According to wellness writer Jo Willey, ‘The breakthrough treatment is being unveiled at the same time that the drug watchdog has recommended it for use on the NHS. Experts say the drug, canagliflozin, which is taken once a day, is a vital new weapon in the battle against the Type 2 diabetes epidemic and its devastating complications. It reduces blood sugar levels in people for whom diet and lifestyle measures or other blood sugar-lowering medicines do not work well enough, say the manufacturers Janssen. The drug, also called Invokana, blocks the re-absorption of glucose in the kidneys, which is instead passed in the urine.’
Professor Anthony Barnett, Emeritus Professor of Medicine at the University of Birmingham, commented, ‘We are seeing a growing number of people with Type 2 diabetes which can have the extremely serious consequences of heart attack, stroke, blindness, kidney failure and amputations. Canagliflozin, which can offer patients significant reductions in blood sugar levels whilst not increasing risks of hypoglycaemia (low blood sugars), represents an important new option in the management of a major UK epidemic.’ The National Institute for Health and Care Excellence (Nice) has given the pill a preliminary positive recommendation, and so the medication could be available within months.
In the Nice draft guidance, canagliflozin was said to be “useful” and recommended for use by some NHS patients with Type 2 diabetes when used in combination with other anti-diabetic drugs. Professor Carole Longson, of Nice, pointed out that ‘Type 2 diabetes can be difficult to treat and most people will eventually require a number of drugs, often used simultaneously. Canagliflozin represents a useful addition to the armoury of anti-diabetic drugs available. Nice is pleased to be able to recommend its use for some people with Type 2 diabetes.’ Dr Peter Barnes, the medical director at Janssen UK, added, ‘With the relentless increase in Type 2 diabetes, there is an ongoing need for additional treatment options. Not only does canagliflozin provide a new once-a-day oral treatment to help control blood glucose levels, it offers real value to the NHS.’
When your wellbeing is affected by type 2 diabetes, this means that your sugar – glucose – levels in your blood have become too high. The chronic disease is associated with 24,000 excess deaths each year, mainly from cardiovascular disease. In the UK, 3.2 million people are diagnosed with diabetes, and type 2 accounts for between 85 and 95% of all people with the disease. Your body develops type 2 diabetes when it can no longer produce insulin, or when the insulin that your body does produced does not work properly.
Typically, type 2 diabetes is treated with a healthy diet, increased physical activity and medication, but this doesn’t always prove effective. The National Diabetes Audit found that more than one in three patients with Type 2 diabetes in England and Wales are currently failing to achieve recommended blood glucose levels. Simon O’Neill of Diabetes UK noted, ‘Developing new treatments that give people more choice about how to manage their condition effectively are really important and so we look forward to seeing the results of the Nice consultation.’
Sexual infidelity is one of the hardest things to come to terms with. It can impact on your emotional wellness and wellbeing in all kinds of ways, and yet it is sadly all too common. To compound this, it’s just impossible to tell, before getting into a relationship, if a man is likely to cheat.
A new book, Why Men Really Cheat, by psychologist Martyn Stewart, looks to answer that big question with a mixture of analysis, case studies and theory. During the course of the book, we are introduced to different male types, the Swinger (no, not that type of swinger), the Enigma and the Opportunist, and we are guided through a series of case studies. We are also shown some pretty serious maths in the form of equations and algorithms to help us work out which personality types are more likely to be cheaters, and why that might be the case.
The conclusions to the very big question of why people chat are varied, ranging from a fear of missing out on an opportunity, having a compulsive sex drive, requiring immediate gratification and seeking some kind of recognition.
In addition to all this, modern technology is making cheating easier than ever. Society is built on ease and instancy, and this is helping to serve people with selfish needs.
The book also details the types of men to avoid, including the Lad’s Lad (a blokish man who is easily swayed by his friends, gets drunk easily and therefore cheats easily), the Manipulator (a cunning and secretive type of man), the Stupid Mistake man, who acts first and then thinks about the consequences later, the Disdainer – a misogynistic type who lacks empathy or patience and is not supportive of women as a gender. Then there’s the Opportunist, a carefree, hedonistic type who will not go out of his way to have an affair but will certainly grab one that arises.
When your wellness is affected by type 1 diabetes, your body doesn’t produce any insulin. This is different from the more common version of the disease – type 2 diabetes – in that type 2 involves your body either not producing enough insulin, or your cells ignoring insulin that is indeed present in your body. There is no cure for type 1 diabetes and so researchers often look into ways to prevent the disease and now a new study, published in the journal Science Translational Medicine, may have found a way to do exactly that.
In an early stage trial, a new vaccine for type 1 diabetes is showing promising results in stalling and preventing the autoimmune disease from manifesting. Up until now, type 1 prevention has revolved around suppressing your immune system, but this method can be damaging to your wellbeing in other ways; increasing your risk of cancer and infections. According to Dr. Richard Insel, chief scientific officer of the Juvenile Diabetes Research Foundation (JDRF), ‘What one really wants to do is tame or regulate the specific aspects of the immune system that have gone awry and leave the rest of the immune system intact.’
For the study, the Netherlands’ Leiden University Medical Centre and California’s Stanford University researchers experimented with the TOL-3021 vaccine, which was genetically altered so that it could shut down your harmful immune system cells without affecting the rest of your system. 80 type 1 diabetics, who were all receiving insulin injections, were given the vaccine for 12 weeks, which appeared to help maintain some insulin-producing beta cells within the pancreas. The vaccine raised people’s levels of C-peptides, which is a sign that the insulin beta cells were working, and lowered the number of immune system-killing T cells.
Study author Dr. Lawrence Steinman, a Stanford professor and the co-founder of company Tolerion – which was created to commercialise the vaccine when it is ready – commented, ‘So far, it looks like it is doing what we want. It looks like it has some potential, but very small numbers.’ The researchers are now designing a new and longer study, with the hope of recruiting as many as 200 patients.
Hardworking men who are exposed to their elements during the course of their daily lives may have to do more than most to protect the wellness and wellbeing of their skin. It is of course exactly this type of man who is unlikely to take anti aging treatments seriously, but it is really worth having a think about how to protect your skin if you want to feel confident, look healthy and avoid unpleasant or unsightly skin problems.
Rough skin is often an issue for working men, and it can be very hard to soften this type of skin and replenish the moisture levels. This can be due to working outdoors or with heavy machinery, or using abrasive materials such as sandpaper. Some parts of your body are more prone to this type of skin, such as the legs, arms and face, plus of course your hands.
Moisturiser is often the best way to address dryness issues, but in the case of persistent dryness you might want to actually seek medical advice to see if an underlying condition such as Psoriasis or Eczema is causing the problems and discomfort for you.
As well as moisturisers, you should also exfoliate gently once a week to get rid of any dead, flaky skin, but this should be done once a week as a maximum.
Oily skin can be as much of a problem as dry skin, too, and contrary to popular belief, it is not caused by eating fast food such as burgers or chips. It is actually your own body that produces the oil, which then clogs your pores and causes bad skin.
To combat oily skin you should avoid using harsh soap and look for a very mild one, plus you could try using clay or mud face masks to help cleanse our skin and restore the natural balance of oil.
When focusing on diet and nutrition, few people think to consider what blood type they are, but new research has shown that this may be the very key to working out what you should be eating. The wellness and wellbeing of those with blood type O Positive has been under the spotlight recently, with recent studies showing that blood type can have a strong effect on how you lose or gain weight, and that this has a relationship with the types of food that you should focus on.
Scientists now believe that if you eat foods that are incompatible with your blood type – even if they are traditionally healthy or diet foods – you are unlikely to lose weight or feel healthy. If you are blood type O Positive, you are probably now wondering what foods you should be eating or avoiding: we have the answers here.
Those with O+ve blood tend to have slightly acidic pH levels, and should thus eat a variety of fruits to help provide an alkalising effect on the body, to normalise the pH levels. Good choices include bananas, plums, prunes, figs, pineapples, black cherry, guavas, blueberries, mangoes and nuts. People with O Positive blood should avoid coconuts, oranges, avocados, blackberries, honeydew and cantaloupe melons, tangerines and strawberries.
Type O individuals also tend to have low hormone levels caused by poor thyroid function. Vegetables such as lettuce, sweet potatoes, onions, pumpkin, broccoli, Swiss chard, parsnips and kale can help to balance things out and strengthen your immune system. You should avoid cabbages, sprouts and cauliflower, as these can exacerbate hormone imbalances.
Eating more protein is extremely advisable for those with Type O blood, and this can come from lean meats such as skinless turkey, chicken, beef and lamb, and egg whites can also be used. Fatty meats should be avoided. Fish is also considered very important, with fish such as salmon, co, kelp, tuna and halibut being particularly helpful.
It is often assumed that when you are suffering from a chronic illness, sexual health is the last thing that you are concerned about. In truth, your sexual wellness and wellbeing is vitally important to you, no matter what other difficulties you may be facing – and this is the case for those who are suffering from type 2 diabetes.
Unfortunately, type 2 diabetes has a number of sexuality issues that often accompany the disease. One of the most serious sexual health issues that affects those with type 2 diabetes is a decrease in libido (also known as a lack of sex drive). This can affect both men and women, and can be a cause of some frustration to those who suffer from the illness. Low libido can be a side effect of the medication taken to control type 2 diabetes, but it can also be the result of some of the symptoms of type 2 diabetes, such as depression, extreme fatigue and lack of energy. Depression and hormonal changes can also be a contributing factor, as well as emotional issues such as stress and anxiety.
Diabetic neuropathy is also a condition that can affect the sexual health of diabetics, as this can result in a feeling of numbness in the genitals, or in some cases the genitals become painful. This can make it impossible to orgasm and can also lead to unenjoyable sex and a lack of response to sexual stimulation.
Sometimes, it can be an emotional issue; when one partner in a relationship becomes a caregiver for the other, when their partner develops diabetes, it can change the dynamic in the relationship and change the way that the partners feel about one another.
Some men also report suffering from erectile dysfunction as a result of their diabetes, which can be caused by muscle, nerve or vascular damage, changes in testosterone or diabetes-related weight issues.
If mango is not on your shopping list, your wellbeing may be suffering as a result. This is according to a number of new and previous studies which suggest that including mango in your diet or in supplement form can have a significant beneficial impact on your wellness, including fighting the good fight against type 2 diabetes and cancer.
Some of the latest information on the health benefits of mangos was presented at the recent Federation of American Societies for Experimental Biology (FASEB) gathering, with researchers noting one study in which obese animals consumed 10 grams of freeze-dried mango every day for 12 weeks. The results of this experiment revealed that the blood sugar levels in the animals declined, which could make mango a helpful tool in your management of type 2 diabetes.
Edralin Lucas, PhD, who led the study, commented, ‘Although the mechanism by which mango exerts its effects warrants further investigation, we do know that mangos contain a complex mixture of polyphenolic compounds.’ Polyphenolic compounds, or polyphenols, are a natural chemical found in plants. There are over 4,000 different polyphenols, which work towards your wellness because they are antioxidants, meaning they fight the disease-causing, cell-damaging free radicals in your body.
However, this study is not the first to find that mango can help to fight diabetes. In 2011, researchers conducted a study in which the explored how freeze-dried mango might lower lipids and tackle diabetes in mice that had been fed a high-fat (HF) diet. Compared to drugs, the researchers found that mango ‘improved glucose tolerance and lipid profile and reduced adiposity [fat] associated with a HF diet.’
If you have, or are at risk of, type 2 diabetes, one thing your doctor might advise you to do is to lose weight – but can mango help with this? Based on studies that indicate African mango extract (Irvingia gabonensis) is effective in reducing body weight and improving metabolic factors in people who are overweight, some experts believe it can. A recent study in the Journal of Dietary Supplements reported on the results of three randomized controlled trials, noting that the studies suggested significant reductions in weight and waist circumference when compared with placebo.
Can Mango Help You to Prevent or Manage Your Diabetes?
There’s no denying that Diabetes is a worldwide epidemic – the condition was found to affect the wellbeing of 370 million people across the globe last year – but 50% of these cases came from Southeast Asia and the Western Pacific. According to a study conducted in New York City, Asian Americans have the highest prevalence of having diabetes or pre-diabetes, with one in every two adults of Asian descent having diabetes or at risk of the disease.
If your body is unable to produce insulin, or unable to properly use and store glucose, this is what’s known as diabetes. Insulin is a hormone made by your pancreas, which is important for your wellness as it helps glucose get into your cells and turn into energy. Usually, your body turns the food you eat into glucose, and the glucose is then used as energy. However, when you have diabetes, this glucose isn’t absorbed but instead builds up in your bloodstream, reaching dangerously high levels.
Diabetes breaks down into two major types; type 1 and type 2. In the case of type 1 diabetes, which is often caused by genetic factors, your body completely stops producing insulin. With type 2 diabetes, which is more related to lifestyle factors, your body is unable to produce insulin and/or it cannot use insulin properly. Of those of Asian American descent with diabetes, up to 95% of cases are type 2.
So why is the disease so prevalent among this population group? Asian Americans who are overweight, have a family history of diabetes, or have a personal history of pre-diabetes or gestational diabetes (diabetes occurring only during pregnancy) are at higher risk of developing type 2 diabetes. More and more Asian Americans have adopted a less active lifestyle and diet of Western food that is low in fiber, high in fat and calories, which has further contributed to the epidemic of type 2 diabetes in Asian Americans.
The problem that then arises is that language barriers and a lack of culturally appropriate diabetes materials make it more difficult for some Asian Americans to achieve good diabetes control. More needs to be done to produce health care providers who understand their cultural values and the unique cultural challenges that Asian Americans may face. That way, this high risk population group can receive individualised treatment, as well as better prevention strategies.
Why are Asian Americans at High Risk of Type 2 Diabetes?
A step forward in gene therapy may mark further benefits for those suffering from Type 1 Diabetes.
By applying gene therapy to dogs for up to four years, minus the effects of hypoglycaemia, the advance could prove advantageous for diabetics. The change from using the methods on mice and using dogs (namely Beagles) instead has shown positive success.
“Moving from mice to large animals is a big step,” said Dr. Fatima Bosch, Director of the Center of Animal Biotechnology and Gene Therapy. “If something works well in large animals, we have reason to believe, based on the previous experience in the field of gene transfer, that it is likely that we will see a similar outcomes in humans. For example, gene therapy that worked well in large animals to treat haemophilia is now seeing positive results in clinical trials with humans. We hope that in a few years, we’ll be able to test this therapy for type 1 diabetes in humans as well.”
The dogs were given insulin and glucokinase through an adenoassociated virus (AAV) vector – a vehicle which transports DNA using a virus that is not designed to harm its host. It can still “infect” them, but the cargo could contain whatever the creator wishes. In this case, the insulin and glocokinase is the cargo, which is beneficial.
Insulin is a very familiar component for those suffering from either type of diabetes, which helps to regulate the glucose in the blood. Whilst naturally created by the pancreas, those suffering from diabetes go through the issue that the pancreas produces too little, meaning that the body’s blood sugar is not regulated properly. Through injections and (or) a healthy diet, this is often maintained quite well. Glucokinase is partnered to insulin, which also helps to regulate the rise and fall of circulating glucose levels.
By injecting them into the dogs, researchers found that the dogs maintained normal blood glucose levels for up to four years without any signs of hypoglycaemia and without any need of further injections.
With further testing proving to be promising, the researchers hope to be able to test on humans in the future.
Type 1 Diabetes – Treatable with Gene Therapy?
The rising epidemic of diabetes worldwide is of major concern to health professionals. Type 2 diabetes, once referred to as late onset diabetes, is a form of the blood disorder where the body fails to produce any or enough insulin to convert the sugar in the blood into glucose that the body’s cells can use.
Like type 1 diabetes – which is less common and is usually diagnosed in early years or before an individual reaches 40 – there is no cure for type 2 diabetes. However, it is possible to prevent the condition from developing.
Following a healthy diet, losing weight and exercising more to control blood sugar levels are all ways in which people can avoid developing diabetes. The majority of those who become diabetic are overweight or clinically obese; they are also likely to display hypertension or high blood pressure; while a history of diabetes in the family will increase an individual’s risk of developing the condition.
If you are concerned that you are at risk of type 2 diabetes or have a history of the disease in your family, you can follow some simple steps to reduce that risk.
To start, find out more about the condition – talk to your doctor and seek out information from charities dedicated to finding a cure for diabetes. Screening can reveal if you are at risk. Becoming more aware of the risks and symptoms of diabetes is a good start to avoiding the disease.
Where necessary change your diet to a healthier one that encourages good glycaemic control and also helps you to lose weight and maintain that weight loss. Again you can get professional advice on nutrition and on following a specific weight loss program. Eating the right amounts and in the right balance of proteins, carbohydrates, fats and sugar will help.
Exercise is crucial and should be incorporated into everyone’s daily routine. Even a gentle stroll will help make you more active while housework and gardening where you work up a sweat and get your heart rate up are ideal.
If you are unfortunate enough to be diagnosed with type 2 diabetes, you can learn to manage and control your condition so that you continue to live a happy, fulfilling life.
How a Change of Lifestyle Can Prevent Type 2 Diabetes
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